Your mind in 20 years is being shaped right now.
From your mid-forties, names take a second longer. Focus slips. Thoughts come a beat slower than they used to.That's normal cognitive ageing and it's been happening for years. But the way the mind ages can be shaped by what we do.
Cognitive change starts earlier than most people think.
Cognitive change starts earlier than most people think.
Midlife is the time to act.
Constance is one place to start.
Founded by Sarah, Cambridge PhD in chemistry
Midlife is the time to act.
Constance is one place to start.
Founded by Sarah, Cambridge PhD in chemistry
A daily habit for your mind. And the hope of lifelong mind-span.
Mind-span is how long the mind stays sharp as the years add up.
That means thinking quickly, finding the word in the moment, holding a train of thought. A mind that still feels like yours.
Constance is a daily capsule and an evening ritual, informed by the science.
A daily habit for your mind. And the hope of lifelong mind-span.
Mind-span is how long the mind stays sharp as the years add up.
That means thinking quickly, finding the word in the moment, holding a train of thought. A mind that still feels like yours.
Constance is a daily capsule and an evening ritual, informed by the science.
Daily Capsules
Softgels combining key parts of the Mediterranean diet: Premium high-polyphenol Extra Virgin Olive Oil, Algal DHA, and Vitamin E.DHA supports the maintenance of normal brain function. Vitamin E helps protect cells from oxidative stress*.
Night
A stir-in powder evening drink. Natural dark-fruit flavours of Fig and pomegranate with lemon balm.Magnesium and vitamin B6 that support normal psychological function. Zinc supports normal cognitive function*. With glycine.
A note from the founder
My nan was called Constance. She was there through every day of my childhood, from the quiet ordinary routine to the special moments. By the end, dementia had hidden her memories, masked her personality, humour, and the way she recognised the people she loved.She's the reason I realised mind-span matters as much as lifespan.This brand is her legacy. To help others age well in mind.
— Sarah, Founder. Cambridge PhD in chemistry.
Constance in her twenties
Age well in mind. For lifelong mind-span.
Be among the first to live with Constance.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. Vitamin E contributes to the protection of cells from oxidative stress. Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Be among the first to live with Constance.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. Vitamin E contributes to the protection of cells from oxidative stress. Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Three capsules. Inspired by the Mediterranean diet. For your mind.
Softgel capsules combining premium early-harvest whole high polyphenol olive oil, vitamin E and algal DHA. DHA supports the maintenance of normal brain function*.Concentrated, batch-verified, every day.
20% off your first order.
Three capsules. Inspired by the Mediterranean diet. For your mind.
Softgel capsules combining premium early-harvest whole high polyphenol olive oil, vitamin E and algal DHA. DHA supports the maintenance of normal brain function*.Concentrated, batch-verified, every day.
20% off your first order. Free for the first 100.
The dietary gap.
The Mediterranean diet is widely admired to support the mind. At its heart sits omega-3 DHA from oily fish, that contributes to the maintenance of normal brain function. Along with extra virgin olive oil, eaten raw, daily, and year-round.In the UK most of us cook with olive oil, which reduces the polyphenols, buy supermarket oil harvested for yield rather than polyphenol content, and don't eat it every day. And many don't eat oily fish weekly.Constance capsules were created to help bridge that gap.
10 x CONCENTRATED
polyphenols vs standard olive oil
PLANT BASED
DHA from algae not fish
WHOLE OILS
Not dried extracts
What's inside.
DHA from Algal oil at 275mg per serving, supports the maintenance of normal brain function.*Vitamin E at 100% of your daily reference intake, helps protect cells from oxidative stress*.Whole extra virgin olive oil selected for its rare high polyphenol concentration, the Mediterranean staple at the core of the formula.
What's inside.
DHA from Algal oil at 275mg per serving, supports the maintenance of normal brain function.*Vitamin E helps protect cells from oxidative stress*.Whole extra virgin olive oil, specially harvested for its rare high polyphenol concentration.
Concentrated, verified, carefully handled
Mediterranean single-origin premium extra virgin oil, cold-pressed and harvested early to maximise polyphenol concentration. That's 10 x the concentration of standard supermarket olive oil. Verified, every batch, by an ISO-accredited lab.DHA directly from the algae that fish eat, that's protected from oxidation.Encapsulated with Vitamin E in a nitrogen-flushed softgel to preserve ingredient quality.
Concentrated, verified by batch.
Mediterranean single-origin premium extra virgin oil, cold-pressed and harvested early to maximise polyphenol concentration. 10 x that of standard supermarket olive oil. Verified, every batch, by an ISO-accredited lab.DHA from Algae that's protected from oxidation.Encapsulated with Vitamin E in a nitrogen-flushed softgel to preserve ingredient quality.
Constance was real.
This brand is named after my nan, Constance. She's the reason I realised mind-span matters as much as lifespan.I built Constance to help others age well in mind.
— Sarah, Founder. Cambridge PhD in chemistry.
Constance in her twenties
Age well in mind. For lifelong mind-span.
Reserve yours and become a founding member.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Daily Capsules are expected to retail at £45 for a 30-day supply. 20% off for founding members.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. This authorised claim is supported by a minimum of 250mg DHA per daily serving. Vitamin E contributes to the protection of cells from oxidative stress.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
An evening ritual. Nutrient-rich, dark-fruit notes. For your mind.
A deep, dark-fruit stir-in powder drink. Fig and pomegranate flavour with lemon balm.
Enriched with magnesium, vitamin B6, zinc and glycine.Magnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*
20% off your first order.
An evening ritual. Nutrient-rich, dark-fruit notes. For your mind.
A deep, dark-fruit stir-in powder drink. Fig and pomegranate flavour with lemon balm.Magnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*
20% off your first order. Free for the first 100.
A way of living.
The Mediterranean diet is admired for its mind-supportive nutrients like magnesium, which contributes to normal psychological function. The lifestyle is about warm, slow evening wind-downs too.Constance NIGHT captures that care in the hours pre-bed.
Natural dark fruit flavours
Fig & pomegranate, with lemon balm
Warm evening wind-down
A pre-bedtime ritual
Mind-supporting nutrients
Magnesium, Zinc, Vitamin B6. With glycine
Dark fruit at dusk.
Fig and pomegranate, deep and naturally sweet, with a lift of lemon balm, a Mediterranean herb with a soft lemon scent.
Dark fruit at dusk.
Fig and pomegranate, deep and naturally sweet. With top-notes of lemon balm, a Mediterranean herb with a soft lemon scent.
Minerals and nutrients for the mind.
Magnesium, zinc and vitamin B6 are readily found in the pumpkin seeds, almonds, pistachios and tahini of the Mediterranean diet.Constance Night includes magnesium at 187.5mg, 50% of your daily reference intake, as gentle glycinate. With vitamin B6 and zinc at 100% of daily reference intakes. Magnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.With glycine at 3g, the simplest of the amino acids and naturally a little sweet.
Minerals and nutrients for the mind.
Magnesium, zinc and vitamin B6 are readily found in the pumpkin seeds, almonds, pistachios and tahini of the Mediterranean diet.Constance Night includes magnesium at 187.5mg, 50% of your daily reference intake, as gentle glycinate. With vitamin B6 and zinc at 100% of daily reference intakes. Magnesium and vitamin B6 support normal psychological function*. Zinc supports normal cognitive function*.With glycine at 3g, the simplest of the amino acids and naturally a little sweet.
Wind down before bed.
One scoop dissolves into warm or cool water. The perfect wind down.
Wind down before bed.
One scoop dissolves into warm or cool water. The perfect wind down.
Constance was real.
This brand is named after my nan, Constance. She's the reason I realised mind-span matters as much as lifespan.I built Constance to help others age well in mind.
— Sarah, Founder. Cambridge PhD in chemistry.
Constance in her twenties
Age well in mind. For lifelong mind-span.
Reserve yours and become a founding member.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Night stir-in powder is expected to retail at £45 for a 30-day supply. 20% off for founding members.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
The science of cognitive longevity.
We look after our bodies to live a long life. Most of us don’t think about our minds in the same way.This page sets out the research behind cognitive longevity, and the idea that how the mind ages can be shaped by what we do.
The science of cognitive longevity.
We look after our bodies to live a long life. Most of us don’t think about looking after our mind.This page sets out the science, and what we can do to shape how the mind ages.
Lifespan, healthspan, and mind-span.
Lifespan is how long you live. Healthspan is how many of those years you spend in good health. Mind-span is the one we think about least, because it’s the hardest to see. It’s how long the mind stays sharp as the years add up.A sharp mind means thinking quickly, finding the word in the moment, the name still there, holding the thread of a thought, knowing why you walked into the room. A mind that still feels like yours.We’re all living longer. There’s no guarantee our minds will keep pace.
How the mind ages.
Some cognitive change is a normal part of getting older. Names take a moment longer, focus wanders more easily. It is ordinary, and it begins earlier than most people expect. One large study measured it from the mid-forties1.But the way the mind ages is not fixed. In a two-year programme of diet, exercise and mental activity, older adults improved their cognition more than those who carried on as usual2, a finding more recent trials have continued to test3.Everyday habits shape how the mind holds up, and midlife is when it starts to really matter.
45 years
the age at which cognitive decline becomes measurable
25%
greater improvement in cognition shown in a 2 year program of diet, exercise & mental activity
7 hours
sleep associated with healthy cognition in published studies
Minerals and nutrients for the mind.
The Mediterranean diet is among the most frequently studied for its links to the ageing brain. Olive oil sits at its centre, consumed raw, daily and year-round, and its polyphenols are some of the most studied components of that diet. Alongside it, the omega-3 DHA from oily fish, eaten weekly.In long-term observational research, regular olive oil users showed slower cognitive decline than those who rarely used it4. It is the whole pattern the research describes, not any single food.
Minerals and nutrients for the mind.
The Mediterranean diet is among the most frequently studied for its links to the ageing brain. Olive oil sits at its centre, consumed raw, daily and year-round, and its polyphenols are some of the most studied components of that diet. Alongside it, the omega-3 DHA from oily fish, eaten weekly.In long-term observational research, regular olive oil users showed slower cognitive decline than those who rarely used it4. It is the whole pattern the research describes, not any single food.
The role of deep sleep.
The mind does some of its most important work while you sleep. During deep sleep, the brain consolidates the day’s memories, which helps everyday recall and focus. Research also suggests it is when the brain clears metabolic waste accumulated during the day.Deep sleep becomes harder to reach as we get older, and around seven hours is the amount most consistently associated with healthy cognition in middle and older age 5. Protecting it, night after night, is one of the quieter ways of shaping your mind in twenty years’ time.
The role of deep sleep.
The mind does some of its most important work while you sleep. During deep sleep, the brain consolidates the day’s memories, which helps everyday recall and focus. Research also suggests it is when the brain clears metabolic waste accumulated during the day.Deep sleep becomes harder to reach as we get older, and around seven hours is the amount most consistently associated with healthy cognition in middle and older age 5. Protecting it, night after night, is one of the quieter ways of shaping your mind in twenty years’ time.
The good news.
No single habit can stop cognitive ageing. But the sum of ordinary choices, repeated through midlife, can change its pace. It’s what you eat, how you move, how you sleep, how you keep your mind active, and more. Whilst there’s much more science has to learn, it’s clear that the mind you have in twenty years is being shaped by the decades in between.That is reason for us all to act.
The good news.
No single habit can stop cognitive ageing. But the sum of ordinary choices, repeated through midlife, can change its pace. It’s what you eat, how you move, how you sleep, how you keep your mind active, and more.Whilst there’s much more science has to learn, it’s clear that the mind you have in twenty years is being shaped by the decades in between.That is reason for us all to act.
References
1. Whitehall II cohort. Singh-Manoux et al. BMJ, 2012.
2. FINGER. Ngandu et al. The Lancet, 2015.
3. US POINTER. Baker et al. 2025.
4. Three-City Study. Berr et al. 2009. Observational.
5. Sleep and cognition. Li et al. Nature Aging, 2022. UK Biobank.
This page describes published, peer-reviewed research, not trials of Constance products.Constance products are food supplements, not medicines. We do not claim to prevent, treat or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.